Neo40®
Neo40®
Neo40®
Neo40®
Neo40®

Neo40®

Neo40®

Neo40® is our flagship Nitric Oxide product, clinically shown to support healthy blood pressure, circulation and energy. Backed by six peer-reviewed, randomized, placebo-controlled trials, Neo40® features a patented, dual-action formula that helps quickly restore and sustain Nitric Oxide levels. It’s the most scientifically studied Nitric Oxide lozenge—and recommended by thousands of healthcare professionals.

    Choose your subscription:

    Automatically charged at the frequency below.
    Buy 1
    SAVE 10% $35.96
    1 Box every 30 days $39.95
    Buy 2 Get 1 Free
    SAVE 40% $71.93
    3 Boxes every 90 days $119.85
    Buy 4 Get 2 Free
    SAVE 40% $143.85
    6 Boxes every 180 days $239.70
    FREE shipping on every delivery
    Cancel or adjust anytime via your online account.

    One-Time Purchase:

    Functional Benefits
    Helps increase Nitric Oxide icon
    Helps increase Nitric Oxide
    Promotes healthy blood flow & circulation icon
    Promotes healthy blood flow & circulation
    Supports healthy blood pressure icon
    Supports healthy blood pressure
    Supports cardiovascular health icon
    Supports cardiovascular health
    Ingredients

    Beetroot from non-GMO beetroot powder that helps supports Nitric Oxide production through the nitrate-nitrite pathway.

    Hawthorn Berry Extract contains high levels of antioxidants (polyphenols) that help activate the key enzyme eNOS, which helps your body quickly convert L-arginine to Nitric Oxide. It also helps reduce nitrite to Nitric Oxide.

    5-MTHF (5’-Methyltetrahydrofolic acid) is used in the synthesis of BH4. Maintaining sufficient levels of this very important co-factor is necessary for proper function of eNOS. If the level of tetrahydrobiopterin is not maintained, the enzyme becomes uncoupled and generates free radicals rather than Nitric Oxide.

    Sodium Nitrite is quickly converted to Nitric Oxide by hawthorn berry extract and has clinically significant vasodilator activity.

    L-citrulline is an effective substitute source for L-arginine, which eNOS converts to Nitric Oxide. It also inhibits arginase, which removes L-arginine from circulation. This then reduces Nitric Oxide production.

    Vitamin B12 reduces direct inhibition of eNOS by homocysteine and production of ADMA (asymmetrical dimethyl-arginine), and helps replenish tetrahydrobiopterin.

    Vitamin C helps prevent removal of Nitric Oxide by free radicals and removes free radicals that inhibit eNOS.

    How to Use

    Place one tablet in your mouth and let it dissolve.

    We recommend an initial Nitric Oxide restoration loading period. During the first 30 to 45 days, take one tablet two times a day, or every 12 hours. This could be one in the morning and one in the evening.

    The Science

    Neo40® is the first dual-pathway Nitric Oxide technology, designed to restore and sustain Nitric Oxide levels as they naturally decline with age. It works through two mechanisms: the nitrate-nitrite reduction pathway, which converts dietary nitrates into nitrite and then into Nitric Oxide; and the enzymatic pathway, which activates endothelial nitric oxide synthase (eNOS) for rapid, consistent production. Backed by more than 15 years of research and patented technology developed in partnership with The University of Texas Health Science Center.

    Other Features and Attributes

    Neo40® is gluten-free, soy-free, dairy-free, caffeine-free, sugar-free, non-GMO and contains no artificial sweeteners. It is third-party tested for purity, potency and safety.
    no1

    Cardiologist recommended beet brand for heart health support*

    The clinical standard in cardiovascular support.

    Helps increase Nitric Oxide

    Promotes healthy blood flow & circulation

    Supports healthy blood pressure

    Supports cardiovascular health

    30-day clinical trial: Neo40® proves effective.

    World-renowned cardiologist Dr. Ernst Schwarz led a research study on Neo40® to determine the effects of oral Nitric Oxide supplementation on blood pressure.

    Randomized, double-blind, placebo-controlled methodology. Subjects did not have hypertension and were not taking any medication for blood pressure. Individual results may vary.

    neo-chart-m

    Powered by cardiovascular science and expertise.

    Neo40®: the clear leader in cardiovascular support.

    Humann

    Others

    The world's first dual-acting Nitric Oxide activator

    Backed by a dozen US and international patents

    Licensed from The University of Texas

    Formulated by leading cardiovascular health experts

    Backed by well-controlled clinical trials published in peer-reviewed journals

    Shop now

    How it works.

    The connection between Nitric Oxide, blood pressure and Neo40®’s patented dual-action technology.

    NEO40-Card1

    Nitric Oxide is essential to every breath you take. The gaseous molecule allows your blood, oxygen and nutrients to travel to every inch of your body—efficiently and effectively.

    NEO40-Card2

    By widening the vessels that promote blood flow, Nitric Oxide allows for healthy blood pressure support and more heart healthy energy.

    NEO40-Card3

    But your Nitric Oxide levels decline with age, which can limit the circulation of vital nutrients and oxygen throughout your body.

    NEO40-Card4

    Neo40®’s patented dual-pathway technology is designed to restore and sustain Nitric Oxide levels, which helps support healthy endothelium function.

    Frequently asked questions.

    Is Neo40® clinically studied?

    Yes. Founded on groundbreaking science with an exclusive patent from The University of Texas Health Science Center, Neo40® is clinically studied to quickly increase your Nitric Oxide levels—and maintain those levels over time to support healthy endothelial function, blood pressure, circulation and heart healthy energy. Plus, it’s an excellent source of vitamin C.

    Is Neo40® sugar free?

    Yes. It's also gluten-free, soy-free, dairy-free, caffeine-free, stimulant-free, non-GMO, and made without any artificial sweeteners. To ensure the highest-quality product, Neo40® is third-party tested for purity, potency and safety.

    What’s in Neo40®'s proprietary Nitric Oxide blend?

    As the only Nitric Oxide tablet backed by US and international patents, Neo40®’s unique clinically studied proprietary Nitric Oxide blend includes:

    Beetroot: Non-GMO beetroot powder clinically demonstrated to be one of the richest whole-food sources of dietary nitrates, which your body converts to Nitric Oxide.

    Hawthorne Berry Extract: Rich in antioxidants that help support Nitric Oxide production.

    L-citrulline: Plays an important role in the conversion of L-arginine to Nitric Oxide.

    Sodium Nitrite: Quickly converted to Nitric Oxide to support healthy blood pressure and overall heart health.

    What are the benefits of Neo40®?

    - Helps increase Nitric Oxide
    - Promotes healthy circulation
    - Supports healthy blood pressure
    - Supports cardiovascular health

    What can I expect to feel when taking Neo40®?

    When taken consistently, many people report feeling more heart healthy energy and support for healthy blood pressure. Individual results may vary.

    Can Neo40® be combined with other Humann products?

    Yes, you can combine this with other Humann products, but we don’t recommend taking more than two total servings in a day. Speak with your physician if you have medical concerns.

    Should I take one or two Neo40® tablets per day?

    You can take two (2) tablets every 12 hours during your first 30 to 45 days. This is known as the restoration loading period. After 30 to 45 days, take only one (1) tablet daily.

    Pro tip: use our Nitric Oxide Indicator Strips™ for the easiest and most efficient way to see if you are Nitric Oxide deficient.

    What’s the best way to take Neo40®?

    Take one tablet daily and allow it to dissolve. Do not swallow the tab whole or place under your tongue.

    How many come in a package?

    Each box of Neo40® contains 30 tabs, which is a one-month supply.

    Shop now

    These statements have not been evaluated by the Food & Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

    *

    According to IQVIA ProVoice Surveys 2025.

    fwpdp