What’s in Neo40®'s proprietary nitric oxide blend?

As the only nitric oxide tablet backed by US and international patents, Neo40®’s unique clinically studied proprietary nitric oxide blend includes:Beetroot: Non-GMO beetroot powder clinically demonstrated to be one of the richest whole-food sources of dietary nitrates, which your body converts to nitric xxide.Hawthorne Berry Extract: Rich in antioxidants that help support nitric oxide production.L-citrulline: Plays an important role in the conversion of L-arginine to nitric oxide.Sodium Nitrite: Quickly converted to nitric oxide to support healthy blood pressure and overall heart health.

What are the benefits of Neo40®?

As the only nitric oxide tablet backed by US and international patents, Neo40®’s unique clinically studied proprietary nitric oxide blend includes:Helps increase nitric oxidePromotes healthy circulationSupports healthy blood pressureSupports cardiovascular health

Neo40®

$39.95

$39.95 $39.95

Neo40®

Name: Neo40®
Brand: HumanN
SKU: 200026
Price: 39.95 USD
Availability: InStock

Clinically Studied

Neo40®

Clinically Studied

Clinically-studied to help support healthy blood pressure
Promotes artery vasodilation for healthy blood flow
Zero sugar and quick-dissolve tablets

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“Great product. I’ve used it for years and love it.”

Chuck H.

Verified User

“Life changing. It performs better than they advertise. I have never taken a vitamin that I could see the results from.”

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Verified User

Made in USA

Third-party tested for purity and potency

Clinically studied ingredient

This product is:

Non-GMO
Zero sugar
Gluten-free

Proprietary Nitric Oxide Blend
420 mg per serving
Beetroot from non-GMO beetroot powder that helps supports nitric oxide production through the nitrate-nitrite pathway.

Hawthorn Berry Extract contains high levels of antioxidants (polyphenols) that help activate the key enzyme eNOS, which helps your body quickly convert L-arginine to nitric oxide. It also helps reduce nitrite to nitric oxide.

Sodium Nitrite is quickly converted to nitric oxide by hawthorn berry extract and has clinically significant vasodilator activity.

L-citrulline is an effective substitute source for L-arginine, which eNOS converts to nitric oxide. It also inhibits arginase, which removes L-arginine from circulation. This then reduces nitric oxide production.

Vitamin C
100 mg per serving
Helps prevent removal of nitric oxide by free radicals and removes free radicals that inhibit eNOS.

Vitamin B12
50 mcg per serving
Reduces direct inhibition of eNOS by homocysteine and production of ADMA (asymmetrical dimethyl-arginine), and helps replenish tetrahydrobiopterin.

Supplement Facts

Amount Per Serving

%DV*

Vitamin C
(as magnesium ascorbate and ascorbic acid)

100 mg

167%

Vitamin B12
(as methylcobalamin)

50 mcg

833%

Proprietary Nitric Oxide
Blend
Beet Root Powder (root),
Hawthorn Berry Extract
(berry), L-citrulline, Sodium
Nitrite

420 mg

*

*Daily Value not established.

Place one tablet in your mouth and let it dissolve.  

We recommend an initial nitric oxide restoration loading period.  

During the first 30 to 45 days, take one tablet two times a day, or every 12 hours. This could be one in the morning and one in the evening.

Neo40® is the first dual-pathway nitric oxide technology, designed to restore and sustain nitric oxide levels as they naturally decline with age.  

It works through two mechanisms: the nitrate-nitrite reduction pathway, which converts dietary nitrates into nitrite and then into nitric oxide; and the enzymatic pathway, which activates endothelial nitric oxide synthase (eNOS) for rapid, consistent production.  

Backed by more than 15 years of research and patented technology developed in partnership with The University of Texas Health Science Center.

Knowledge center

Full Ingredients List

Proprietary Nitric Oxide Blend
420 mg per serving
Beetroot from non-GMO beetroot powder that helps supports nitric oxide production through the nitrate-nitrite pathway.

Hawthorn Berry Extract contains high levels of antioxidants (polyphenols) that help activate the key enzyme eNOS, which helps your body quickly convert L-arginine to nitric oxide. It also helps reduce nitrite to nitric oxide.

Sodium Nitrite is quickly converted to nitric oxide by hawthorn berry extract and has clinically significant vasodilator activity.

L-citrulline is an effective substitute source for L-arginine, which eNOS converts to nitric oxide. It also inhibits arginase, which removes L-arginine from circulation. This then reduces nitric oxide production.

Vitamin C
100 mg per serving
Helps prevent removal of nitric oxide by free radicals and removes free radicals that inhibit eNOS.

Vitamin B12
50 mcg per serving
Reduces direct inhibition of eNOS by homocysteine and production of ADMA (asymmetrical dimethyl-arginine), and helps replenish tetrahydrobiopterin.

Supplement Facts

Amount Per Serving

%DV*

Vitamin C
(as magnesium ascorbate and ascorbic acid)

100 mg

167%

Vitamin B12
(as methylcobalamin)

50 mcg

833%

Proprietary Nitric Oxide
Blend
Beet Root Powder (root),
Hawthorn Berry Extract
(berry), L-citrulline, Sodium
Nitrite

420 mg

*

*Daily Value not established.

Patented nitric oxide technology

Neo40 is the first dual-pathway nitric oxide technology designed to restore and sustain nitric oxide levels as they decline with age.

#1 trusted by cardiologists, doctors, and scientists.

Humann is the standard in science-led blood pressure support and used by over 6,000 medical practitioners and professionals.†

“What’s most important to me is that my patients are getting good outcomes.”

Dr. Christopher Davis, MD, FACC

Chief Cardiologist at Humann, Triple Board-Certified Interventional Cardiologist, Fellow of the American College of Cardiology

“I trust Humann’s products because they go above and beyond for quality & research.”

Dr. Yousef Elyaman, MD, IFMCP

Medical Director at Humann, Board Certified in Internal Medicine and Integrative Medicine from the American Board of Physician Specialties

“Humann is the leader in cardiovascular health. There is no one else even close.”

Dr. John Ivy, PhD

Teresa Lozano Long Endowed Chair Emeritus at the University of Texas, Exercise Physiologist and Author of over 190 scientific papers

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A man in a gray long-sleeve shirt holds a SuperBeets Heart Chew

Did you know?

Brain blood flow is critical to help support overall cognitive health.

Meet Nitric Oxide:
The Miracle Molecule

Did you know that Nitric Oxide is one of the most important molecules produced in your body?

An educational health card with a dark reddish-brown background, featuring white text about nitric oxide production in blood vessels.

A dark informational graphic with white text reading 'Widens' and 'Nitric oxide helps widen your blood vessels,' plus simple arrows and vein-like line illustrations.

A dark promotional graphic with white text reading 'Oxygen + nutrients = Delivers' and 'Circulating vital oxygen and nutrients to your 36 trillion cells.' The background is a dark gradient with subtle red and black tones and faint circular diagram elements.

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Your questions,
answered.

Yes. Founded on groundbreaking science with an exclusive patent from The University of Texas Health Science Center, Neo40® is clinically studied to quickly increase your nitric oxide levels—and maintain those levels over time to support healthy endothelial function, blood pressure, circulation and heart healthy energy. Plus, it’s an excellent source of vitamin C.

Yes. It's also gluten-free, soy-free, dairy-free, caffeine-free, stimulant-free, non-GMO, and made without any artificial sweeteners. To ensure the highest-quality product, Neo40® is third-party tested for purity, potency and safety. 

As the only nitric oxide tablet backed by US and international patents, Neo40®’s unique clinically studied proprietary nitric oxide blend includes:

Beetroot: Non-GMO beetroot powder clinically demonstrated to be one of the richest whole-food sources of dietary nitrates, which your body converts to nitric xxide.
Hawthorne Berry Extract: Rich in antioxidants that help support nitric oxide production.
L-citrulline: Plays an important role in the conversion of L-arginine to nitric oxide.
Sodium Nitrite: Quickly converted to nitric oxide to support healthy blood pressure and overall heart health.

As the only nitric oxide tablet backed by US and international patents, Neo40®’s unique clinically studied proprietary nitric oxide blend includes:

Helps increase nitric oxide
Promotes healthy circulation
Supports healthy blood pressure
Supports cardiovascular health

When taken consistently, many people report feeling more heart healthy energy and support for healthy blood pressure. Individual results may vary.

Yes, you can combine this with other Humann products, but we don’t recommend taking more than two total servings in a day. Speak with your physician if you have medical concerns.

You can take two (2) tablets every 12 hours during your first 30 to 45 days. This is known as the restoration loading period. After 30 to 45 days, take only one (1) tablet daily.

Take one tablet daily and allow it to dissolve. Do not swallow the tab whole or place under your tongue.

Each box of Neo40® contains 30 tabs, which is a one-month supply.