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Neo40 Professional
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Where science-born innovation meets cardiovascular health.
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It all started with Neo40 Professional — the first dual-acting nitric oxide activator in the world.
Neo40 Professional was born from patented nitric oxide research at the University of Texas Health Science Center and is trusted by thousands of medical professionals.
Clinically studied in six peer-reviewed trials, it supports cardiovascular health and healthy blood pressure, forming the foundation of Humann’s professional cardiovascular portfolio.
It started with a bold question born out of research from The University of Texas.
How can we get the body to make more nitric oxide?
They found the answer and entrusted it to a team who would assume the mantle, and build a business capable of the mission. In partnership with The University of Texas and a program created by a Nobel Laureate + academic researchers - and that's how Humann was born.
Not just science-backed. Science-born.
Official Cardiovascular Supplement of Texas Athletics
Our Science
The molecule that changed everything.
In 1998, Dr. Ferid Murad was one of three research scientists awarded the Nobel Prize for the discovery of nitric oxide's role as a signaling molecule in the cardiovascular system. It signals blood vessels to dilate, stay smooth, and allow for better blood flow. It’s blood flow that supports oxygen delivery, and nutrient transport—supporting your brain health, energy, performance, and longevity. The body makes nitric oxide naturally. But as we age, we make less. A lot less, starting as early as our 20s.
Nitric oxide (N.O.) production begins declining by one’s mid-twenties
Decline in production is further accelerated by poor diet and lack of exercise
By age 40, humans produce 50% or less of the N.O. they did at age 20
Trusted by people who don't just message trust - they measure it.
We are founded on Nobel Prize-Winning Science. Validated in Real Life.
Yousef Elyaman, MD
Medical Director at Humann, Board Certified in Internal Medicine and Integrative Medicine from the American Board of Physician Specialties
Penny Kris-Etherton, PhD
Science Advisory Board Member at Humann, past chair of the American Heart Association Council on Lifestyle and Cardiometabolic Health
President of Humann’s Science Advisory Board, University of Texas Professor Emeritus, Department of Kinesiology and Health Education
Dr. Christopher Davis, MD, FACC
Chief Cardiologist at Humann, Triple Board-Certified Interventional Cardiologist, Fellow of the American College of Cardiology
Dr. John P. Cooke, MD, PhD
Science Advisory Board Member at Humann, Chair of the Department of Cardiovascular Sciences at the Houston Methodist Research Institute
8 published
clinical studies
Humann invests in rigorous, peer-reviewed clinical research to validate real-world cardiovascular benefits. Clinicians can trust the safety and efficacy of our products and confidently integrate them into practice protocols.
Testimonial
“I know of no other company that puts cardiovascular health at the center of their research and development. And being a functional medicine physician that teaches other doctors and other practitioners about cardiovascular health, it really was a match made in heaven because our missions aligned.”
— Dr. Yousef Elyaman, MD, IFMCP
MEDICAL DIRECTOR AT HUMANN
Exclusive insights and education from leading experts.
Unlock interviews, podcasts, and on-demand education from leading cardiovascular experts.
Nitric Oxide: Athletes to Everyday
What fuels athletes can also support longevity. Dr. John Ivy and Dr. Christopher Davis, MD, FACC explain how optimizing nitric oxide boosts endurance, recovery, and heart health.
Understanding True “Normal” Blood Pressure
Many patients appear healthy while vascular damage progresses silently. Dr. Christopher Davis, MD, FACC explains what HCPs need to know to assess real cardiovascular risk.
Oxidative Stress, Aging & Nitric Oxide with Dr. Cheryl Burdette
Dr. Cheryl Burdette explains how oxidative stress drives aging—and how nitric oxide, diet, and antioxidants can help protect your cells and support lasting health.